منابع مشابه
Synthesis of 2-phenylthiazolidine derivatives as cardiotonic agents. II. 2-(Phenylpiperazinoalkoxyphenyl)thiazolidine-3-thiocarboxamid es and the corresponding carboxamides.
(IV, V, and X). Structure-activity relationships (SAR) were investigated by varying the structural parameters. Transposition of the piperazinoalkoxyl group to the meta or para position from the ortho position caused a marked fall in activity. Conversion of the thiocarboxamido to a carboxamido group caused a marked increase in activity. This tendency was generally observed in this series of comp...
متن کاملSynthesis and Antimicrobial Activities of 5-Arylidene-thiazolidine-2,4-dione Derivatives
Antibiotic resistance is considered one of the world's major public health concerns. The main cause of bacterial resistance is the improper and repeated use of antibiotics. To alleviate this problem, new chemical substances against microorganisms are being synthesized and tested. Thiazolidines are compounds having many pharmacological activities including antimicrobial activities. For this purp...
متن کاملSynthesis and evaluation of antioxidant activity of some new benzylidene-thiazolidine-xanthine derivatives.
UNLABELLED The International Diabetes Federation reported that 246 million adults worldwide had diabetes mellitus and the prevalence of this syndrome was expected to increase continuously. AIM To design new compound with potential antidiabetic and antioxidant activity. MATERIAL AND METHODS New benzylidene-thiazolidine derivatives (BT2a-2e) were obtained by condensation of xanthine-thiazolid...
متن کاملMicrowave-assisted synthesis and evaluation of N-substituted thiazolidine-2, 4-dione derivatives as antimicrobial agents
A series of N-substituted thiazolidine-2,4-dione derivatives bearing potentially bioactive substituents were synthesized by microwave irradiation method. Structural elucidation was accomplished by 1H NMR, 13C NMR, IR, Mass and elemental analyses. The synthesized compounds were evaluated for antimicrobial activities. Among the compounds studied, compounds 4i and 4d showed potent antimicrobial ac...
متن کاملA facile synthesis and antimicrobial activity evaluation of sydnonyl-substituted thiazolidine derivatives.
Some new sydnonyl-substituted thiazolidine derivatives were synthesized in high yields by the modified Knoevenagel condensation of 3-aryl-4-formylsydnones with thiazolidine-2,4-dione and 2-thioxo-thiazolidine-4-one, respectively. All the synthesized thiazolidine derivatives were screened by paper-disc method to identify their antimicrobial activities against three bacteria viz. Staphylococcus a...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1953
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.73.9_949